Therapeutic applications of thyroid hormone analogues

Actions of Thyroid Hormone Analogues on Chemokines

The extracellular domain of plasma membrane integrin αvβ3 contains a receptor for thyroid hormone (L-thyroxine, T4; 3,5,3'-triiodo-L-thyronine, T3); this receptor also binds tetraiodothyroacetic acid (tetrac), a derivative of T4. Tetrac inhibits the binding of T4 and T3 to the integrin. Fractalkine (CX3CL1) is a chemokine relevant to inflammatory processes in the CNS that are microglia-dependen...

Therapeutic applications of vitamin D analogues.

In the sunnier parts of the world a dietary intake of vitamin D is unnecessary,* but for most of us it is a true vitamin. Its dihydroxylated metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2DO) is, however, a hormone synthesised in the kidney and borne by the bloodstream to distant target organs (gut, bone, and possibly the parathyroid glands) with a complex feedback mechanism regulating its rate ...

Thyroid hormone analogues: their role in treatment of hyperlipidemia

Thyroid hormones are central regulators of lipid metabolism and energy homeostasis, which primarily act through Thyroid Hormone Receptors (TRs). Selective Thyroid Hormone Receptor Modulators (STRMs) are chemical analogues of thyroid hormone, designed to preferentially induce beneficial actions of thyroid hormone through specificity for TRβ (isoform specificity) and specific accumulation in live...

Environmental chemicals as thyroid hormone analogues: new studies indicate that thyroid hormone receptors are targets of industrial chemicals?

Thyroid hormone (TH) is essential for normal brain development, but the specific actions of TH differ across developmental time and brain region. These actions of TH are mediated largely by a combination of thyroid hormone receptor (TR) isoforms that exhibit specific temporal and spatial patterns of expression during animal and human brain development. In addition, TR action is influenced by di...

Thyroid Stimulating Hormone Thyroid Stimulating Hormone